Killing the 2 guards is barely enough to make a 8 boost 21 possible on Agent. Once you left the hut, the table and the cabinets are unloaded so they are irrelevant to lag. The guards chase after you though. If the guards are not alive, not running their AI scripts saves a very small amount of time.
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The "last piece of the puzzle" found by Berg during his strategising for the [https://rankings.the-elite.net/~berg/time/206357 agent untied], and measured as saving a surprising 0.10-0.15s on console. Also called "eliminating the hut guards", it just involves tossing a grenade very imprecisely in the hut somewhere to kill both of the guards there. This is incredibly free and should be used by all players.
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The thinking is that these guards spend a significant part of the run aiming at Bond down the entire length of the runway, and the end of the run is already more laggy due to explosions and other runway guards. It has always been done on SA out of necessity - these guards regularly blow up the plane - but on agent it was assumed that the extra grenade explosion would just make more lag, and so cost time if anything.